The Effects of Simvastatin on Ischemia Reperfusion Injury in an Experimental Colon Anastomosis Model

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dc.contributor.authorAkarsu, Mahmut
dc.contributor.authorSaygun, Oral
dc.contributor.authorAydinuraz, Kuzey
dc.contributor.authorAydin, Oktay
dc.contributor.authorDaphan, Cagatay Erden
dc.contributor.authorTanrikulu, Fatma Benli
dc.contributor.authorComu, Faruk Metin
dc.date.accessioned2020-06-25T18:22:39Z
dc.date.available2020-06-25T18:22:39Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Aydin, Oktay/0000-0001-5728-0128
dc.description.abstractAnastomotic leakage is more frequently reported in colonic anastomoses. Ischemia reperfusion injury is one of the main reasons for anastomotic leakage. Simvastatin is known to prevent tissue damage induced by free oxygen radicals after ischemia reperfusion injury. The effect of simvastatin on colonic anastomosis impaired by ischemia reperfusion injury is investigated. Single layer, end-to-end colocolic anastomosis after 0.5-cm colon resection was performed in Wistar Albino rats. In Group 1 (control) (n= 10), colonic anastomosis without I-R was performed. In Group 2 (n = 10), the superior mesenteric artery was clamped for 10 min followed by 60 min of reperfusion after which resection anastomosis was performed. In Group 3 (n= 10), 10 mg/kg simvastatin was given by gavage for 7 days after I-R and resection anastomosis. In Group 4 (n = 10), the rats received 10 mg/kg simvastatin by gavage 7 days before and 7 days after ischemia reperfusion and surgery. All of the rats were sacrificed 8 days after surgery. Anastomotic bursting pressure and tissue hydroxyproline levels were measured. Postoperative administration of simvastatin restored the anastomotic bursting pressure and hydroxyproline levels to that of control group thus overcoming the effect of ischemia reperfusion injury. Simvastatin administered postoperatively in an experimental model of colonic resection anastomosis impaired by ischemia reperfusion injury increased anastomotic bursting pressures and tissue hydroxyproline levels. Further experimental and clinical studies will show whether administration of simvastatin will increase reliability of the anastomosis and decrease postoperative morbidity and mortality in colonic anastomosis after ischemia reperfusion injury.en_US
dc.identifier.citationAkarsu, M., Saygun, O., Aydinuraz, K., Aydin, O., Daphan, C. E., Tanrıkulu, F. B., Kisa, U., & Comu, F. M. (2017). The Effects of Simvastatin on Ischemia Reperfusion Injury in an Experimental Colon Anastomosis Model. The Indian journal of surgery, 79(5), 390–395.en_US
dc.identifier.doi10.1007/s12262-016-1493-y
dc.identifier.endpage395en_US
dc.identifier.issn0972-2068
dc.identifier.issn0973-9793
dc.identifier.issue5en_US
dc.identifier.pmid29089696
dc.identifier.scopus2-s2.0-84965056664
dc.identifier.scopusqualityQ4
dc.identifier.startpage390en_US
dc.identifier.urihttps://doi.org/10.1007/s12262-016-1493-y
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6852
dc.identifier.volume79en_US
dc.identifier.wosWOS:000417692500005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal Of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSuperior mesenteric artery occlusionen_US
dc.subjectSimvastatinen_US
dc.subjectColonen_US
dc.subjectAnastomotic healingen_US
dc.subjectIschemia reperfusionen_US
dc.subjectRaten_US
dc.titleThe Effects of Simvastatin on Ischemia Reperfusion Injury in an Experimental Colon Anastomosis Modelen_US
dc.typeArticle

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