Differential expression patterns of metastasis suppressor proteins in basal cell carcinoma

Basit Öğe Kaydı
dc.contributor.authorBozdogan, Onder
dc.contributor.authorYulug, Isik G.
dc.contributor.authorVargel, Ibrahim
dc.contributor.authorCavusoglu, Tarik
dc.contributor.authorKarabulut, Ayse A.
dc.contributor.authorKarahan, Gurbet
dc.contributor.authorSayar, Nilufer
dc.date.accessioned2020-06-25T18:13:03Z
dc.date.available2020-06-25T18:13:03Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionSayar Atasoy, Nilufer/0000-0002-3247-613X
dc.description.abstractBackgroundBasal cell carcinomas (BCCs) are common malignant skin tumors. Despite having a significant invasion capacity, they metastasize only rarely. Our aim in this study was to detect the expression patterns of the NM23-H1, NDRG1, E-cadherin, RHOGDI2, CD82/KAI1, MKK4, and AKAP12 metastasis suppressor proteins in BCCs. MethodsA total of 96 BCC and 10 normal skin samples were included for the immunohistochemical study. Eleven frozen BCC samples were also studied by quantitative real time polymerase chain reaction (qRT-PCR) to detect the gene expression profile. ResultsNM23-H1 was strongly and diffusely expressed in all types of BCC. Significant cytoplasmic expression of NDRG1 and E-cadherin was also detected. However, AKAP12 and CD82/KAI1 expression was significantly decreased. The expressions of the other proteins were somewhere between the two extremes. Similarly, qRT-PCR analysis showed down-regulation of AKAP12 and up-regulation of NM23-H1 and NDRG1 in BCC. Morphologically aggressive BCCs showed significantly higher cytoplasmic NDRG1 expression scores and lower CD82/KAI1 scores than non-aggressive BCCs. ConclusionThe relatively preserved levels of NM23-H1, NDRG1, and E-cadherin proteins may have a positive effect on the non-metastasizing features of these tumors.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-108S184]; Local Ethical Committee - KirikkaleKirikkale University [07.04.2008/ 2008-039]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technical Research Council of Turkey (TUBITAK) (grant no. SBAG-108S184). The project was approved by the Local Ethical Committee - Kirikkale (07.04.2008/ 2008-039).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/ijd.12581
dc.identifier.endpage915en_US
dc.identifier.issn0011-9059
dc.identifier.issn1365-4632
dc.identifier.issue8en_US
dc.identifier.pmid25428551
dc.identifier.scopus2-s2.0-84937027371
dc.identifier.scopusqualityQ1
dc.identifier.startpage905en_US
dc.identifier.urihttps://doi.org/10.1111/ijd.12581
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6113
dc.identifier.volume54en_US
dc.identifier.wosWOS:000358125100018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleDifferential expression patterns of metastasis suppressor proteins in basal cell carcinomaen_US
dc.typeArticle

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