Effects of Supplemental Epigallocatechin Gallate in the Diet of Broilers Exposed to Fluoride Intoxication

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dc.contributor.authorAydogan, Ilkay
dc.contributor.authorKarsli, Mehmet Akif
dc.contributor.authorBasalan, Mehmet
dc.contributor.authorYildirim, Ebru
dc.contributor.authorCinar, Miyase
dc.contributor.authorSen, Goekhan
dc.contributor.authorSumer, Tugce
dc.date.accessioned2020-06-25T18:29:21Z
dc.date.available2020-06-25T18:29:21Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.description.abstractWe evaluated the effects of dietary epigallocatechin gallate (EGCG) on the performance, biochemical parameters, and liver histopathology of fluoride-intoxicated broiler chickens. In total, 160 1-day-old male broiler chicks (Ross PM3 strain) were collected and assigned to four groups (40 animals each), with four replicates. The control group received a basal diet; the F group received 800mg/kg fluoride; the EGCG group received 400mg/kg EGCG; and the EGCG+F group received 400mg/kg EGCG and 800mg/kg fluoride. The live weight (LW) of F-treated chicks was significantly lower than that of the controls. In the F-treated groups, feed intake (FI) and LW values were lower, but the feed conversion ratio (FCR) was higher than those of the controls. The ratio of heart weight to LW was found to be the highest in the F-treated groups. Alkaline phosphatase (ALP), aspartate aminotransferase (AST), and total oxidant status (TOS) levels in the F-treated groups were significantly higher, whereas the increase in total cholesterol levels was insignificant than those in the control group. In the EGCG+F group, AST, total cholesterol, and TOS levels decreased to a level comparable to those in the control group. Histopathological evaluation revealed that there were mild changes in the portal region in the EGCG+F group; additionally, there was an improvement in liver morphology in the EGCG+F group compared to that in the F group. Thus, EGCG has potent antioxidant and regenerative effects that can ameliorate the detrimental effects of fluoride toxicity on blood parameters and the liver.en_US
dc.description.sponsorshipScientific Research Fund in the University of KirikkaleKirikkale University [2014/126]en_US
dc.description.sponsorshipThis research was supported by the Scientific Research Fund in the University of Kirikkale (Project No: 2014/126).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s12011-018-1306-1
dc.identifier.endpage266en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid29549531
dc.identifier.scopus2-s2.0-85044017953
dc.identifier.scopusqualityQ1
dc.identifier.startpage258en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-018-1306-1
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7257
dc.identifier.volume186en_US
dc.identifier.wosWOS:000446972000027
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant statusen_US
dc.subjectBiochemical parametersen_US
dc.subjectBroiler performanceen_US
dc.subjectEpigallocatechinen_US
dc.subjectFluoride toxicityen_US
dc.subjectLiver histopathologyen_US
dc.titleEffects of Supplemental Epigallocatechin Gallate in the Diet of Broilers Exposed to Fluoride Intoxicationen_US
dc.typeArticle

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