In vitro antibacterial effects of topical local anesthetics

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dc.contributor.authorSedef Gocmen, J.
dc.contributor.authorBuyukkocak, Unase
dc.contributor.authorCaglayan, Osman
dc.contributor.authorAksoy, Altan
dc.date.accessioned2020-06-25T17:48:03Z
dc.date.available2020-06-25T17:48:03Z
dc.date.issued2008
dc.description.abstractBackground: The antibacterial activities of local anesthetics are recognized. Objective: To investigate in vitro the activity of topical local anesthetic ointments at clinical doses. Methods: The activity of two different local anesthetic ointments including lidocaine 5% and lidocaine/prilocaine 2.5% was tested against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Streptococcus pyogenes and Enterococcus faecalis by the disc-diffusion method. Sterile discs containing topical local anesthetic drugs were prepared taking into account the doses of ointments used in clinical practice. The validity of the methodology was confirmed using topical antibacterial mupirocin. The inhibition zones of the discs were measured. Results: Mupirocin inhibited all the bacteria. Both local anesthetic ointments were found to be most effective on E. coli, whereas they had no effects on P. aeruginosa. Lidocaine 5% revealed antibacterial activity against S. aureus, S. epidermidis, E. coli, S. pyogenes and E. faecalis, but lidocaine/prilocaine 2.5% showed no activity on E. faecalis and inhibited S. pyogenes only at double doses. It was also observed that the antibacterial activity was in a dose-dependent manner. Conclusion: In the light of these findings, it might be concluded that topical local anesthetic ointments in routine settings may have a preventive role against some bacteria.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/09546630802050498
dc.identifier.endpage353en_US
dc.identifier.issn0954-6634
dc.identifier.issn1471-1753
dc.identifier.issue6en_US
dc.identifier.pmid18608709
dc.identifier.scopus2-s2.0-56549113369
dc.identifier.scopusqualityQ1
dc.identifier.startpage351en_US
dc.identifier.urihttps://doi.org10.1080/09546630802050498
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4269
dc.identifier.volume19en_US
dc.identifier.wosWOS:000260926400005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Dermatological Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial activityen_US
dc.subjectlocal anestheticsen_US
dc.subjecttopicalen_US
dc.titleIn vitro antibacterial effects of topical local anestheticsen_US
dc.typeArticle

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