Elevated Tear Human Neutrophil Peptides 1-3, Human Beta Defensin-2 Levels and Conjunctival Cathelicidin LL-37 Gene Expression in Ocular Rosacea
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To investigate the role of innate immunity in ocular rosacea. Methods: Thirty-two patients with ocular rosacea patients (group-1) and 28 healthy volunteers (group-2) who served as controls were enrolled in the study. Tear function parameters were assessed, conjunctival impression cytology was performed and tear samples were collected. Human-neutrophil-peptides (HNP) 1?3 and human-beta-defensin-2 (hBD-2) levels were measured in tears by using ELISA tests. Cathelicidin leucin-leucin-37 (LL-37), hBD-2, human-beta-defensin-9 (hBD-9) gene expression levels were measured in the conjunctival impression cytology samples using real-time polymerase chain reaction. Results: Tear HNP1-3 (p?=?0.024), hBD-2 (p?<?0.001), conjunctival LL-37 gene expression rate (p?=?0.014) and ocular surface disease index scores (p?=?0.001) were higher and the tear break-up time was lower (p?=?0.003) in group-1. No other differences were found between the groups. Conclusion: The results of this study suggest the role of abnormal innate immunity in the pathophysiology of ocular rosacea by revealing elevated antimicrobial peptide levels.
Açıklama
Gokcinar, Nesrin Buyuktortop/0000-0001-7795-5188; YILDIRAN, Fatma Azize BUDAK/0000-0001-7031-6834
Anahtar Kelimeler
Antimicrobial peptides, cathelicidin, defensins, innate immunity, ocular, rosacea
Kaynak
Ocular Immunology And Inflammation
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
27
Sayı
7
Künye
closedAccess
