Elevated Tear Human Neutrophil Peptides 1-3, Human Beta Defensin-2 Levels and Conjunctival Cathelicidin LL-37 Gene Expression in Ocular Rosacea

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dc.contributor.authorGokcinar, Nesrin Buyuktortop
dc.contributor.authorKarabulut, Ayse Anil
dc.contributor.authorOnaran, Zafer
dc.contributor.authorYumusak, Erhan
dc.contributor.authorYildiran, Fatma Azize Budak
dc.date.accessioned2020-06-25T18:30:30Z
dc.date.available2020-06-25T18:30:30Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionGokcinar, Nesrin Buyuktortop/0000-0001-7795-5188; YILDIRAN, Fatma Azize BUDAK/0000-0001-7031-6834
dc.description.abstractPurpose: To investigate the role of innate immunity in ocular rosacea. Methods: Thirty-two patients with ocular rosacea patients (group-1) and 28 healthy volunteers (group-2) who served as controls were enrolled in the study. Tear function parameters were assessed, conjunctival impression cytology was performed and tear samples were collected. Human-neutrophil-peptides (HNP) 1?3 and human-beta-defensin-2 (hBD-2) levels were measured in tears by using ELISA tests. Cathelicidin leucin-leucin-37 (LL-37), hBD-2, human-beta-defensin-9 (hBD-9) gene expression levels were measured in the conjunctival impression cytology samples using real-time polymerase chain reaction. Results: Tear HNP1-3 (p?=?0.024), hBD-2 (p?<?0.001), conjunctival LL-37 gene expression rate (p?=?0.014) and ocular surface disease index scores (p?=?0.001) were higher and the tear break-up time was lower (p?=?0.003) in group-1. No other differences were found between the groups. Conclusion: The results of this study suggest the role of abnormal innate immunity in the pathophysiology of ocular rosacea by revealing elevated antimicrobial peptide levels.en_US
dc.description.sponsorshipKirikkale University of Scientific and Technological Research Center (KUBTUAM)en_US
dc.description.sponsorshipLaboratory analyses were performed in Kirikkale University of Scientific and Technological Research Center (KUBTUAM) with the above mentioned financial support. The authors want to thank to biology experts Esra G?nayd?n and Asl? Agar for ELISA and RT-PCR performed in KUBTUAM.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/09273948.2018.1504971
dc.identifier.endpage1183en_US
dc.identifier.issn0927-3948
dc.identifier.issn1744-5078
dc.identifier.issue7en_US
dc.identifier.pmid30142005
dc.identifier.scopus2-s2.0-85052314146
dc.identifier.scopusqualityQ1
dc.identifier.startpage1174en_US
dc.identifier.urihttps://doi.org/10.1080/09273948.2018.1504971
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7659
dc.identifier.volume27en_US
dc.identifier.wosWOS:000492182300024
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofOcular Immunology And Inflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial peptidesen_US
dc.subjectcathelicidinen_US
dc.subjectdefensinsen_US
dc.subjectinnate immunityen_US
dc.subjectocularen_US
dc.subjectrosaceaen_US
dc.titleElevated Tear Human Neutrophil Peptides 1-3, Human Beta Defensin-2 Levels and Conjunctival Cathelicidin LL-37 Gene Expression in Ocular Rosaceaen_US
dc.typeArticle

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