Experimental Chronic Toxoplasmosis Model in Mice: Brain Lesions and Related Behavioral Changes

Basit Öğe Kaydı
dc.contributor.authorKocak, Orhan Murat
dc.contributor.authorAtmaca, Hasan Tarik
dc.contributor.authorTerzi, Osman Safa
dc.contributor.authorBuyukkayaer, Seyhan
dc.contributor.authorOzdemir, Hatice
dc.contributor.authorUzunalioglu, Tuba
dc.contributor.authorKul, Oguz
dc.date.accessioned2020-06-25T18:06:49Z
dc.date.available2020-06-25T18:06:49Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionDINCEL, Gungor Cagdas/0000-0002-6985-3197; Terzi, Osman Safa/0000-0002-7877-8897
dc.description.abstractObjective: In this study, it is aimed to constitute a chronic toxoplasmosis model using toxoplasma gondii (T. gondii) ME49 strain that is supposed to produce tissue cysts, to compare healthy and infected mice in terms of behavioral changes. In addition, the relationship between behavioral changes and brain lesions was questioned. Method: Before experimental application, out of a total of twenty-one 2-month-old Swiss albino mice, T. gondii antibody-free, 14 were infected by intraperitoneal (IP) (n=8) or oral (n=6) inoculation of 2x102 Toxoplasma gondii ME49 oocysts. Four months later, fear-and anxiety-related behavioral changes in infected and healthy control groups were comparatively evaluated with plus-maze test. At the end of the experiment (45 day after inoculation), euthanasia was carried out on all mice and their brains were examined histopathologically and immunohistochemically for the presence of T. gondii tissue cysts. Results: Infected mice had low levels of anxiety, they have entered the open arms more frequently and have spent more time in the open arms of the maze compared to controls. Pathologically, in the infected group, high rates of gliosis, perivascular cell infiltration, meningitis, and neuron necrosis were observed especially in the parietal and temporal lobes, cornu ammonis, amygdala, and thalamus compared to the other parts of the brain. A higher number of tissue cyst formations were positively correlated with the lesion severity in these parts of the brain. Conclusion: It can be suggested that, tissue cysts and neuropathological changes in chronically infected mice brains have direct concern with behavioral manipulation which results from low anxiety levels. (Archives of Neuropsychiatry 2012; 49: 139-144)en_US
dc.identifier.citationKoçak O. M., Atmaca H. T., Terzi O. S., Büyükkayaer S., Rezaki H. Ö., Uzunalioglu T., Cağdaş G. D., Bal E., Kul O. (2012). Deneysel kronik toksoplazmoz fare modeli: Beyin lezyonlarının davranış değişiklikleri ile ilişkilendirilmesi. Nöropsikiyatri Arşivi, 49(2), 139 - 144.en_US
dc.identifier.doi10.4274/npa.y6302
dc.identifier.endpage144en_US
dc.identifier.issn1300-0667
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84863882800
dc.identifier.scopusqualityQ3
dc.identifier.startpage139en_US
dc.identifier.trdizinidtrdizinikyoktur
dc.identifier.urihttps://doi.org/10.4274/npa.y6302
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5364
dc.identifier.volume49en_US
dc.identifier.wosWOS:000305733300011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofNoropsikiyatri Arsivi-Archives Of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectToxoplasma gondiien_US
dc.subjectmiceen_US
dc.subjecttissue cysten_US
dc.subjectbehavioren_US
dc.titleExperimental Chronic Toxoplasmosis Model in Mice: Brain Lesions and Related Behavioral Changesen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
2303e501-dad1-495c-b7c1-034b70324a24.pdf
Boyut:
2.08 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu