In Vitro Investigation of the Antibacterial Effect of Ketamine

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dc.contributor.authorGocmen, Sedef
dc.contributor.authorBuyukkocak, Unase
dc.contributor.authorCaglayan, Osman
dc.date.accessioned2020-06-25T17:48:07Z
dc.date.available2020-06-25T17:48:07Z
dc.date.issued2008
dc.description.abstractBackground: Antibacterial activity of local anesthetics especially lidocaine has been shown previously. In this study, the antibacterial effect of ketamine, a general anesthetic agent was investigated. Methods: The antibacterial effect of ketamine was studied using six different strains of bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Entecoccus faecalis, Streptococcus pyogenes, Pseudomonas aeruginosa and Escherichia coli) with disc diffusion method. Ciprofloxacine discs (CIP, oxoid) were used as a control to verify the methodology. Minimal inhibition concentration (MIC) and minimal bactericidal concentration (MBC) of ketamine for these bacteria were also determined. Results: No inhibition was evident in discs containing 62.5 mu g of ketamine. Ketamine 125 mu g showed activity on all the bacteria tested with the exception of E. coli. The inhibition rates of Ketamine were more prominent at the doses of 250 mu g and 500 mu g similar to the inhibition rate of CIP. Whereas MIC and MBC values of ketamine for S. aureus and S. pyogenes were 500 mu g mL(-1), MIC and MBC values for P. aeruginosa were above 2000 mu g mL(-1). For other bacteria, these values ranged between these levels. Conclusions: Ketamine with higher doses showed antibacterial activity. We thought that it will be proper to use ketamine hesitantly in experimental animal studies like sepsis and translocation.en_US
dc.identifier.citationGocmen S., Buyukkocak U., & Caglayan O. (2008). In Vitro Investigation of the Antibacterial Effect of Ketamine. Upsala Journal of Medical Sciences, 113(1), 39-46.en_US
dc.identifier.doi10.3109/2000-1967-211
dc.identifier.endpage45en_US
dc.identifier.issn0300-9734
dc.identifier.issn2000-1967
dc.identifier.issue1en_US
dc.identifier.pmid18521797
dc.identifier.scopus2-s2.0-48949097980
dc.identifier.scopusqualityQ1
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org10.3109/2000-1967-211
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4311
dc.identifier.volume113en_US
dc.identifier.wosWOS:000263415100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofUpsala Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKetamineen_US
dc.subjectantibacterial activityen_US
dc.titleIn Vitro Investigation of the Antibacterial Effect of Ketamineen_US
dc.typeArticle

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