Does Subclinical Hypothyroidism Affect Dynamic Thiol/Disulfide Homeostasis and ischemia-modified Albumin Levels in Children?
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
COLL PHYSICIANS & SURGEONS PAKISTAN
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To determine the effects of subclinical hypothyroidism on oxidative stress in children. Study Design: A cross-sectional study. Place and Duration of Study: Department of Paediatrics, Paediatric Endocrinology, and General Outpatient Clinics, Kirikkale University, School of Medicine, from May 2017 to October 2018. Methodology: This study included 92 subjects aged between 2 and 18 years. The subjects were divided into two groups. Forty-seven children with subclinical hypothyroidism and 45 healthy controls were evaluated. In order to evaluate oxidative damage, native thiol, total thiol, disulfides, their ratios, and ischemia-modified albumin (IMA) levels were compared between the two groups. The relationship between TSH and IMA levels was assessed. Results: Age and gender were not significantly different in the two groups. Native thiol, total thiol, disulfides and their ratios were similar in the two groups. lschemia-modified albumin levels were significantly higher in the patient group than the controls (p<0.001). There was no correlation between TSH and IMA levels in the patient group (r=0.069 p=0.645). Conclusion: Subclinical hypothyroidism may be related to the impairment of IMA, and have a neutral effect on thiol/disulfide balance. Further research is needed to explain the effects of oxidative stress in subclinical hypothyroidism.
Açıklama
karahan, irfan/0000-0003-4669-1751
Anahtar Kelimeler
Subclinical hypothyroidism, Childhood, Oxidative stress
Kaynak
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
30
Sayı
7
Künye
Tursun S, Alpcan A, Ergur AT, Karahan I, Neselioglu S, Erel O. (2020). Does Subclinical Hypothyroidism Affect Dynamic Thiol / Disulfide Homeostasis and İschemia-modified Albumin Levels in Children?. J Coll Physicians Surg Pak; 30(7):726-729.
