Does Subclinical Hypothyroidism Affect Dynamic Thiol/Disulfide Homeostasis and ischemia-modified Albumin Levels in Children?

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dc.contributor.authorTursun, Serkan
dc.contributor.authorAlpcan, Aysegul
dc.contributor.authorErgur, Ayca Torel
dc.contributor.authorKarahan, Irfan
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorErel, Ozcan
dc.date.accessioned2021-01-14T18:10:31Z
dc.date.available2021-01-14T18:10:31Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionkarahan, irfan/0000-0003-4669-1751
dc.description.abstractObjective: To determine the effects of subclinical hypothyroidism on oxidative stress in children. Study Design: A cross-sectional study. Place and Duration of Study: Department of Paediatrics, Paediatric Endocrinology, and General Outpatient Clinics, Kirikkale University, School of Medicine, from May 2017 to October 2018. Methodology: This study included 92 subjects aged between 2 and 18 years. The subjects were divided into two groups. Forty-seven children with subclinical hypothyroidism and 45 healthy controls were evaluated. In order to evaluate oxidative damage, native thiol, total thiol, disulfides, their ratios, and ischemia-modified albumin (IMA) levels were compared between the two groups. The relationship between TSH and IMA levels was assessed. Results: Age and gender were not significantly different in the two groups. Native thiol, total thiol, disulfides and their ratios were similar in the two groups. lschemia-modified albumin levels were significantly higher in the patient group than the controls (p<0.001). There was no correlation between TSH and IMA levels in the patient group (r=0.069 p=0.645). Conclusion: Subclinical hypothyroidism may be related to the impairment of IMA, and have a neutral effect on thiol/disulfide balance. Further research is needed to explain the effects of oxidative stress in subclinical hypothyroidism.en_US
dc.identifier.citationTursun S, Alpcan A, Ergur AT, Karahan I, Neselioglu S, Erel O. (2020). Does Subclinical Hypothyroidism Affect Dynamic Thiol / Disulfide Homeostasis and İschemia-modified Albumin Levels in Children?. J Coll Physicians Surg Pak; 30(7):726-729.en_US
dc.identifier.doi10.29271/jcpsp.2020.07.726
dc.identifier.endpage729en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue7en_US
dc.identifier.pmid32811603
dc.identifier.scopus2-s2.0-85089647175
dc.identifier.scopusqualityQ2
dc.identifier.startpage726en_US
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2020.07.726
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12649
dc.identifier.volume30en_US
dc.identifier.wosWOS:000561256500010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCOLL PHYSICIANS & SURGEONS PAKISTANen_US
dc.relation.ispartofJCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSubclinical hypothyroidismen_US
dc.subjectChildhooden_US
dc.subjectOxidative stressen_US
dc.titleDoes Subclinical Hypothyroidism Affect Dynamic Thiol/Disulfide Homeostasis and ischemia-modified Albumin Levels in Children?en_US
dc.typeArticle

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