Effects of ozone therapy and taurine on ischemia/reperfusion-induced testicular injury in a rat testicular torsion model

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dc.contributor.authorAydos, Tolga Resat
dc.contributor.authorBasar, Mehmet Murad
dc.contributor.authorKul, Oguz
dc.contributor.authorAtmaca, Hasan Tank
dc.contributor.authorUzunalioglu, Tuba
dc.contributor.authorKisa, Ucler
dc.contributor.authorEfe, Oguzhan Ekin
dc.date.accessioned2020-06-25T18:12:25Z
dc.date.available2020-06-25T18:12:25Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Aydos, Tolga Resat/0000-0002-1832-9336; ATMACA, HASAN TARIK/0000-0001-8379-4114
dc.description.abstractBackground/aim: To investigate the effect of ozone and/or taurine treatment comparatively on testicular damage due to ischemia/reperfusion (I/R) injury in an experimental torsion model in rats. Materials and methods: Adult Wistar rats with and without torsion/detorsion were used. In order to monitor the effect of ozone and/or taurine treatment on testicular damage due to I/R injury, following histopathological investigation apoptotic indexes were scored by TUNEL method. Moreover, tumor necrosis factor receptor 1 (TNFR1), caspase 3, caspase 8, endothelial nitric oxide synthase (eNOS), tumor necrosis factor alpha (TNF alpha), and cytochrome C immunostainings were performed and the levels of malondialdehyde, glutathione peroxidase, superoxide dismutase, catalase, total sulthydryl, and nitric oxide were determined in the testicular tissue. Results: Intraperitoneal ozone and/or taurine treatment prevented both histopathological damage and increase in the apoptotic index. Torsion did not exert an effect on the levels of TNFa and cytochrome C. Ozone and/or taurine treatment prevented increases in TNFR1, caspase 3, and caspase 8. The level of oxidative stress markers was unchanged. The increases in NO level and eNOS expression were prevented by ozone and/or taurine treatment in I/R groups. Conclusion: Using ozone therapy and/or taurine before reperfusion may be a solution for germ cell degeneration resulting from testicular torsion and related infertility.en_US
dc.description.sponsorship1002 TOBITAK Short-Term R&D Funding ProgramTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [110S273]en_US
dc.description.sponsorshipThis study was supported by the 1002 TOBITAK Short-Term R&D Funding Program (Project No. 110S273).en_US
dc.identifier.citationAydos T. R., Başar M. M., Kul O., Atmaca H. T., Uzunalioğlu T., Kısa Ü., Efe O. E. (2014). Effects of ozone therapy and taurine on ischemia/reperfusion-induced testicular injury in a rat testicular torsion model. Turkish Journal of Medical Sciences, 44(5), 749 - 755.en_US
dc.identifier.doi10.3906/sag-1308-20
dc.identifier.endpage755en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.pmid25539540
dc.identifier.scopus2-s2.0-84905672828
dc.identifier.scopusqualityQ1
dc.identifier.startpage749en_US
dc.identifier.trdizinid213165
dc.identifier.urihttps://doi.org/10.3906/sag-1308-20
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5906
dc.identifier.volume44en_US
dc.identifier.wosWOS:000343068800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOzone therapyen_US
dc.subjecttaurineen_US
dc.subjectischemia/reperfusionen_US
dc.subjectraten_US
dc.subjecttestisen_US
dc.subjectoxidative stressen_US
dc.titleEffects of ozone therapy and taurine on ischemia/reperfusion-induced testicular injury in a rat testicular torsion modelen_US
dc.typeArticle

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