The comparison of pleurodesis effects of iodopovidone at different concentrations and magnesium silicate: An experimental study

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dc.authoridAtasoy, Pinar/0000-0002-5603-8265
dc.contributor.authorZorlu, Ekin
dc.contributor.authorKur, Salih
dc.contributor.authorPekcan, Zeynep
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorGunal, Nesimi
dc.contributor.authorDural, Koray
dc.contributor.authorOzpolat, Berkant
dc.date.accessioned2025-01-21T16:34:34Z
dc.date.available2025-01-21T16:34:34Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: This experimental study aims to investigate the pleurodesis effects of iodopovidone at different concentrations (2% and 4%) and sterile talc in a rat model. Methods: Forty male Wistar Albino rats were randomly divided into four equal groups including 10 rats in each group. Groups 1, 2, and 3 were designed as the study, and Group 4 as the control group. In Group 1, 4 g sterile talc was given in the slurry form at 20 mL 0.9% saline solution, in Group 2 and Group 3 10% iodopovidone solution were given at 4% and 2% concentrations, respectively, and in Group 4, 0.9% saline was only administrated as 3 mL into the pleural space. All rats were sacrificed on Day 30 and evaluated for macroscopic and microscopic examination. Microscopic evaluation was performed for alveolar collapse, alveolar hemorrhage, alveolar infiltration and fibrosis. Brain, liver, and kidney tissues were also examined. Results: Iodopovidone macroscopically caused a significant adhesion similar to sterile talc at a concentration of 4%. The pleurodesis effect of iodopovidone at a concentration of 4% was significantly similar to talc, when microscopic parameters were evaluated. Granulomas due to sterile talc were observed in the opposite hemithorax. Brain, liver, and kidney examinations revealed no systemic distribution for both agents. Conclusion: Iodopovidone is a powerful alternative to sterile talc with its easy accessibility and low cost. In this study, 4% iodopovidone was found to provide effective and safe pleurodesis in rats. We believe that the use of this concentration in clinical studies would provide more effective results.
dc.identifier.doi10.5606/tgkdc.dergisi.2021.20664
dc.identifier.endpage512
dc.identifier.issn1301-5680
dc.identifier.issue4
dc.identifier.pmid35096448
dc.identifier.scopus2-s2.0-85118683709
dc.identifier.scopusqualityQ3
dc.identifier.startpage503
dc.identifier.trdizinid503222
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2021.20664
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay503222
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23987
dc.identifier.volume29
dc.identifier.wosWOS:000709895700011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayincilik
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectChemical pleurodesis; iodopovidone; malignant pleural effusion; sterile talc
dc.titleThe comparison of pleurodesis effects of iodopovidone at different concentrations and magnesium silicate: An experimental study
dc.title.alternativeİodopovidonun farklı konsantrasyonları ile magnezyum silikatın plörodez etkilerinin karşılaştırılması: Deneysel çalışma
dc.typeArticle

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