Trapidil, an inhibitor for phosphodiesterase and platelet-derived-growth factor, ameliorates corrosive esophageal burn in rats
Yükleniyor...
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tohoku Univ Medical Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Corrosive esophageal burn is a common health problem in the pediatric age group and causes serious esophageal injuries. The medical treatment In acute phase of corrosive esophageal injury is of particular importance for prevention of esophageal stricture. We therefore aimed to investigate the possible beneficial effect of trapidil (triazolopyrimidine), an inhibitor for phosphodiesterase and platelet-derived-growth-factor, during acute phase of esophageal corrosive injury. Wistar albino rats were randomly allocated to untreated, treated, and sham-operated groups (n = 10 for each group). Corrosive esophageal burn was generated with 10% NaOH solution. The rats were left untreated (untreated group) or treated with trapidil as a single dose of 40 mg/kg intraperitoneally after one hour of the injury (treated group). Abdominal esophageal segment was isolated and tied in sham-control group. The studied esophageal segment was removed from each animal after 24 hours. Malondialdehyde (MDA) and nitric oxide (NO) levels were measured in the esophageal tissues. The ulcer depth was graded by histopathologic examination. MDA and NO levels were significantly higher in the untreated group than in the treated group. Namely, trapidil treatment significantly decreased MDA and NO levels in the injured tissues, the levels of which are similar to those in the tissues of control animals. The grades of ulcer depth were significantly improved in the treated group. These results indicate that the reactive oxygen radicals increase in the early phase of corrosive esophagitis and cause tissue damage. We suggest that trapidil treatment may be useful in acute phase of corrosive esophageal injury.
Açıklama
Anahtar Kelimeler
corrosive esophagitis, free oxgen radicals, trapidil, triazolopyrimidine
Kaynak
Tohoku Journal Of Experimental Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
207
Sayı
3
Künye
Somuncu, S., Cakmak, M., Erdogan, S., Caglayan, O., Akman, H., & Kaya, M. (2005). Trapidil, an inhibitor for phosphodiesterase and platelet-derived-growth factor, ameliorates corrosive esophageal burn in rats. The Tohoku journal of experimental medicine, 207(3), 203–208. https://doi.org/10.1620/tjem.207.203
