Trapidil, an inhibitor for phosphodiesterase and platelet-derived-growth factor, ameliorates corrosive esophageal burn in rats

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dc.contributor.authorSomuncu, Salih
dc.contributor.authorÇakmak, Murat
dc.contributor.authorErdoğan, Sibel
dc.contributor.authorÇağlayan, Osman
dc.contributor.authorAkman, Hülya
dc.contributor.authorKaya, Murat
dc.date.accessioned2020-06-25T17:40:21Z
dc.date.available2020-06-25T17:40:21Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description.abstractCorrosive esophageal burn is a common health problem in the pediatric age group and causes serious esophageal injuries. The medical treatment In acute phase of corrosive esophageal injury is of particular importance for prevention of esophageal stricture. We therefore aimed to investigate the possible beneficial effect of trapidil (triazolopyrimidine), an inhibitor for phosphodiesterase and platelet-derived-growth-factor, during acute phase of esophageal corrosive injury. Wistar albino rats were randomly allocated to untreated, treated, and sham-operated groups (n = 10 for each group). Corrosive esophageal burn was generated with 10% NaOH solution. The rats were left untreated (untreated group) or treated with trapidil as a single dose of 40 mg/kg intraperitoneally after one hour of the injury (treated group). Abdominal esophageal segment was isolated and tied in sham-control group. The studied esophageal segment was removed from each animal after 24 hours. Malondialdehyde (MDA) and nitric oxide (NO) levels were measured in the esophageal tissues. The ulcer depth was graded by histopathologic examination. MDA and NO levels were significantly higher in the untreated group than in the treated group. Namely, trapidil treatment significantly decreased MDA and NO levels in the injured tissues, the levels of which are similar to those in the tissues of control animals. The grades of ulcer depth were significantly improved in the treated group. These results indicate that the reactive oxygen radicals increase in the early phase of corrosive esophagitis and cause tissue damage. We suggest that trapidil treatment may be useful in acute phase of corrosive esophageal injury.en_US
dc.identifier.citationSomuncu, S., Cakmak, M., Erdogan, S., Caglayan, O., Akman, H., & Kaya, M. (2005). Trapidil, an inhibitor for phosphodiesterase and platelet-derived-growth factor, ameliorates corrosive esophageal burn in rats. The Tohoku journal of experimental medicine, 207(3), 203–208. https://doi.org/10.1620/tjem.207.203en_US
dc.identifier.doi10.1620/tjem.207.203
dc.identifier.endpage208en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue3en_US
dc.identifier.pmid16210831
dc.identifier.scopus2-s2.0-27744518988
dc.identifier.scopusqualityQ1
dc.identifier.startpage203en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.207.203
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3406
dc.identifier.volume207en_US
dc.identifier.wosWOS:000232286600004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal Of Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcorrosive esophagitisen_US
dc.subjectfree oxgen radicalsen_US
dc.subjecttrapidilen_US
dc.subjecttriazolopyrimidineen_US
dc.titleTrapidil, an inhibitor for phosphodiesterase and platelet-derived-growth factor, ameliorates corrosive esophageal burn in ratsen_US
dc.typeArticle

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