Effects of different anesthetic techniques on serum leptin, C-reactive protein, and cortisol concentrations in anorectal surgery

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dc.contributor.authorBüyükkoçak, Ünase
dc.contributor.authorDaphan, Çağatay
dc.contributor.authorÇağlayan, Osman
dc.contributor.authorAydinuraz, Kuzey
dc.contributor.authorKaya, Tahsin
dc.contributor.authorSaygun, Oral
dc.contributor.authorAğalar, Fatih
dc.date.accessioned2020-06-25T17:41:19Z
dc.date.available2020-06-25T17:41:19Z
dc.date.issued2006
dc.description.abstractAim To compare the effects of intratracheal general anesthesia (ITGA) and regional (saddle block) anesthesia on leptin, C-reactive protein (CRP), and cortisol blood concentrations during anorectal surgery. Methods Fifty-eight patients suffering from hemorrhoidal disease, pilonidal sinus, anal fissure, or anal fistula were included the study. Patients were randomly assigned into one of the two groups (n = 29). Patients in one group received ITGA. After thiopental and fentanyl induction, vecuronium was used as a muscle relaxant. Anesthesia was maintained with sevoflurane. In the other group we applied saddle block, injecting hyperbaric bupivacaine into the subarachnoid space, through the L3-L4 intervertebral space, in the sitting position. Blood samples were collected for leptin, CRP, and cortisol analysis before the induction of anesthesia at 3 and 24 hours postoperatively. Results Preoperative leptin, CRP, and cortisol concentrations were comparable between the groups. There was no significant difference in postoperative levels of leptin and CRP in both groups. Although not significant, leptin and CRP concentrations were lower in the saddle block group at three hours postoperatively (mean SD, 6.95 +/- 8.59 and 6.02 +/- 12.25, respectively) than in the ITGA group (mean SD, 9.04 +/- 9.89 and 8.40 +/- 15.75, respectively). During early postoperative period, cortisol increased slightly in the ITGA group and remained at similar level in the saddle block group, but later decreased in both groups. Cortisol levels in the saddle block group were significantly lower than in the ITGA group at 3 hours postoperatively (343.7 +/- 329.6 vs 611.4 +/- 569.8; P = 0.034). Conclusion Saddle block, a regional anesthetic technique, may attenuate stress response in patients undergoing anorectal surgery, by blocking afferent neural input during early postoperative period.en_US
dc.identifier.citationBuyukkocak, U., Daphan, C., Caglayan, O., Aydinuraz, K., Kaya, T., Saygun, O., & Agalar, F. (2006). Effects of different anesthetic techniques on serum leptin, C-reactive protein, and cortisol concentrations in anorectal surgery. Croatian medical journal, 47(6), 862-868.en_US
dc.identifier.endpage868en_US
dc.identifier.issn0353-9504
dc.identifier.issn1332-8166
dc.identifier.issue6en_US
dc.identifier.pmid17167859
dc.identifier.scopus2-s2.0-33845906353
dc.identifier.scopusqualityQ2
dc.identifier.startpage862en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3682
dc.identifier.volume47en_US
dc.identifier.wosWOS:000243266800009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedicinska Nakladaen_US
dc.relation.ispartofCroatian Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffects of different anesthetic techniques on serum leptin, C-reactive protein, and cortisol concentrations in anorectal surgeryen_US
dc.typeArticle

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