Cafeteria diet can cause systemic inflammation and oxidative damage in the various tissues

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dc.authoridKarahan, İrfan/0000-0003-4669-1751
dc.contributor.authorTursun, Serkan
dc.contributor.authorŞahin, Yaşar
dc.contributor.authorAlcigir, Mehmet Eray
dc.contributor.authorÇınar, Miyase
dc.contributor.authorKarahan, İrfan
dc.date.accessioned2025-01-21T16:36:17Z
dc.date.available2025-01-21T16:36:17Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBACKGROUND: Cafeteria diet (CAF) is a succesful tool for establishing animal obesity model. This study purposed to show immunoexpression and oxidant-antioxidant status in the various organ tissues of Wistar rats fed CAF. METHODS: Two groups (six rats per group) of Wistar albino rats were fed CAF and standard chow (control) diets for eight weeks. After experimental procedure, the animals were sacrificed. Intestine, stomach, liver, kidney, spleen, heart, lung, and pancreas tissues were sent to Pathology Department and inducible nitric oxide synthase (iNOS), nuclear factor-kappa B (NF-kappa B) and cannabinoid receptor-1 (CB-1) immunoexpressions were assessed. Also, plasma liver function tests and lipid levels were measured total oxidant capacity (TOC) and total antioxidant capacity (TAC) were evaluated in both plasma and liver tissue. RESULTS: The immunoexpressions of NF-kappa B, iNOS and CB-1 were higher in the experiment group for all tissues. TOC was significantly higher in the experiment group, for both plasma and liver tissue (p < 0.001 and p = 0.02). TAC was higher in the experiment group's plasma measurement (p = 0.02), while there was no difference in the liver tissue between experiment and control groups (p = 0.11). CONCLUSION: CAF-induced obesity may be related to increased immunoexpression and oxidative damage in the various organs. Systemic problems should be considered and these phenomenon should be studied more comprehensively.
dc.identifier.doi10.3233/MNM-230068
dc.identifier.endpage91
dc.identifier.issn1973-798X
dc.identifier.issn1973-7998
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85188776318
dc.identifier.scopusqualityQ3
dc.identifier.startpage81
dc.identifier.urihttps://doi.org/10.3233/MNM-230068
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24289
dc.identifier.volume17
dc.identifier.wosWOS:001208593400007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIos Press
dc.relation.ispartofMediterranean Journal of Nutrition and Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectCafeteria diet; obesity; immunoexpression; oxidative stress; total antioxidant capacity
dc.titleCafeteria diet can cause systemic inflammation and oxidative damage in the various tissues
dc.typeArticle

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