Evaluation of the Neurotoxicity of the Polyethylene Glycol Hydrogel Dural Sealant
Yükleniyor...
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Neurosurgical Soc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
AIM: Although polyethylene glycol (PEG) is a neutral, biocompatible hydrophilic polymer recognized for its lack of interaction with biological barrier, its neurotoxicity has not been clearly identified in neurosurgery. This study is constructed to evaluate the possible neurotoxicity of a PEG hydrogel dural sealant. MATERIAL and METHODS: After a burrhole was opened in the left parietal bone of the twenty five Wistar albino rats, the dura mater and cerebral cortex were incised and the experimental material (activated polyethylene glycol and polyethylene imine) was sprayed into the burrhole. Then brain tissues were harvested for histopathological and biochemical studies at 72 hours to investigate the acute stage changes and on 15th day to evaluate the chronic stage changes. RESULTS: There were statistically significant differences among the groups regarding the comparison of the values of the PMNL cell infiltration grades, gliosis and congestion in both acute and chronic stages. However, the values of the MNL cell infiltration grades, edema and fibrin formation, lipid peroxidation levels of harvested brain tissues were similar in all groups. CONCLUSION: Although this study did not present the detailed histopathological and biochemical evaluation results, it indicated that the application of the PEG-based hydrogel sealant was not associated with neurotoxicity, delayed healing, or degenerative changes.
Açıklama
Anahtar Kelimeler
Polyethylene glycol, Hydrogel, Dural sealant, Neurotoxicity
Kaynak
Turkish Neurosurgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
23
Sayı
1
Künye
Bakar B., Köse E. A., Balcı M., Atasoy P., Sarkaratı B., Alhan A., Kılınç K., Keskıl I. S. (2013). Evaluation of the neurotoxicity of the polyethylene glycol hydrogel dural sealant. Turkish Neurosurgery, 23(1), 16 - 24.
