Evaluation of the Neurotoxicity of the Polyethylene Glycol Hydrogel Dural Sealant

Basit Öğe Kaydı
dc.contributor.authorBakar, Bulent
dc.contributor.authorKose, Emine Arzu
dc.contributor.authorBalci, Mahi
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorSarkarati, Bahram
dc.contributor.authorAlhan, Aslihan
dc.contributor.authorKeskil, Ismail Semih
dc.date.accessioned2020-06-25T18:07:32Z
dc.date.available2020-06-25T18:07:32Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAIM: Although polyethylene glycol (PEG) is a neutral, biocompatible hydrophilic polymer recognized for its lack of interaction with biological barrier, its neurotoxicity has not been clearly identified in neurosurgery. This study is constructed to evaluate the possible neurotoxicity of a PEG hydrogel dural sealant. MATERIAL and METHODS: After a burrhole was opened in the left parietal bone of the twenty five Wistar albino rats, the dura mater and cerebral cortex were incised and the experimental material (activated polyethylene glycol and polyethylene imine) was sprayed into the burrhole. Then brain tissues were harvested for histopathological and biochemical studies at 72 hours to investigate the acute stage changes and on 15th day to evaluate the chronic stage changes. RESULTS: There were statistically significant differences among the groups regarding the comparison of the values of the PMNL cell infiltration grades, gliosis and congestion in both acute and chronic stages. However, the values of the MNL cell infiltration grades, edema and fibrin formation, lipid peroxidation levels of harvested brain tissues were similar in all groups. CONCLUSION: Although this study did not present the detailed histopathological and biochemical evaluation results, it indicated that the application of the PEG-based hydrogel sealant was not associated with neurotoxicity, delayed healing, or degenerative changes.en_US
dc.identifier.citationBakar B., Köse E. A., Balcı M., Atasoy P., Sarkaratı B., Alhan A., Kılınç K., Keskıl I. S. (2013). Evaluation of the neurotoxicity of the polyethylene glycol hydrogel dural sealant. Turkish Neurosurgery, 23(1), 16 - 24.en_US
dc.identifier.doi10.5137/1019-5149JTN.6039-12.1
dc.identifier.endpage24en_US
dc.identifier.issn1019-5149
dc.identifier.issue1en_US
dc.identifier.pmid23344862
dc.identifier.scopus2-s2.0-84874819013
dc.identifier.scopusqualityQ3
dc.identifier.startpage16en_US
dc.identifier.trdizinid150872
dc.identifier.urihttps://doi.org/10.5137/1019-5149JTN.6039-12.1
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5601
dc.identifier.volume23en_US
dc.identifier.wosWOS:000334560700003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolyethylene glycolen_US
dc.subjectHydrogelen_US
dc.subjectDural sealanten_US
dc.subjectNeurotoxicityen_US
dc.titleEvaluation of the Neurotoxicity of the Polyethylene Glycol Hydrogel Dural Sealanten_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
1822f3ec-75aa-43d3-acf6-5b1a78e5e49e.pdf
Boyut:
355.93 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Daha fazla yükle