Effects of Algan Hemostatic Agent on bleeding time in a rat tail hemorrhage model

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dc.contributor.authorTotuk, Ozgan Melike Gedar
dc.contributor.authorGuzel, Sevket Ergun
dc.contributor.authorEkici, Husamettin
dc.contributor.authorKumandas, Ali
dc.contributor.authorAydingoz, Selda Emre
dc.contributor.authorYilmaz, Enis Cagatay
dc.contributor.authorKirdan, Taylan
dc.date.accessioned2021-01-14T18:10:21Z
dc.date.available2021-01-14T18:10:21Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionEkici, Husamettin/0000-0001-6403-737X
dc.description.abstractBACKGROUND: Algan Hemostatic Agent (AHA) is a multi-herbal extract containing a standardized amount of Achillea millefolium, Juglans regia, Lycopodium clavatum, Rubus caesius or Rubis fruciosus, Viscum album, and Vitis vinifera, each of which is effective in hemostasis. In this study, we aimed to investigate the effects of AHA on bleeding time in a rat tail hemorrhage model. METHODS: Forty-eight Sprague Dawley rats (5-7 weeks old, 180-210 g) were randomly and equally allocated to six groups as follows: heparin plus saline (heparinized control), heparin plus AHA-soaked sponge, heparin plus liquid form of AHA, saline (non-heparinized control), AHA-soaked sponge and liquid form of AHA. Heparin (640 IU/kg) was administered intraperitoneally three times a day for three days in heparinized groups. For the bleeding model, the tail of rats was transected. According to the study group, either saline- or AHA-soaked sponge or liquid form of AHA was applied over the hemorrhage area. In AHA- or saline-soaked sponge groups, once the bleeding time had started, it was checked every 10 seconds. If the bleeding did not stop after 40 seconds, it was accepted as a failure. In liquid AHA group, the duration of bleeding was measured using a chronometer and defined as the time (seconds) from wounding until the bleeding stopped. RESULTS: Bleeding time in the heparinized and non-heparinized control groups was over 40 seconds. After applying the sponge form of AHA on the wound area, bleeding time was significantly shortened to less than 20 seconds in both heparinized and non-heparinized rats (p<0.001 for both). The liquid form of AHA stopped bleeding in 5.0 +/- 1.2 seconds and 8.0 +/- 1.3 seconds in heparinized and non-heparinized groups, respectively. CONCLUSION: AHA is a highly effective topical hemostatic agent in a rat tail hemorrhage model, thus may provide for a unique clinically effective option for control of bleeding during surgical operations or other emergencies.en_US
dc.identifier.citationÖzgün Melike Gedar Totuk, Şevket Ergun Güzel, Hüsamettin Ekici, Ali Kumandaş, Selda Emre Aydıngöz, Enis Çağatay Yılmaz, Taylan Kırdan, Ahmet Midi. Effects of Algan Hemostatic Agent on bleeding time in a rat tail hemorrhage model. Ulus Travma Acil Cerrahi Derg. 2020; 26(6): 853-858.en_US
dc.identifier.doi10.14744/tjtes.2020.50384
dc.identifier.endpage858en_US
dc.identifier.issn1306-696X
dc.identifier.issue6en_US
dc.identifier.pmid33107963
dc.identifier.scopus2-s2.0-85094882945
dc.identifier.scopusqualityQ3
dc.identifier.startpage853en_US
dc.identifier.trdizinid424056
dc.identifier.urihttps://doi.org/10.14744/tjtes.2020.50384
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12537
dc.identifier.volume26en_US
dc.identifier.wosWOS:000582710000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTURKISH ASSOC TRAUMA EMERGENCY SURGERYen_US
dc.relation.ispartofULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlgan Hemostatic Agenten_US
dc.subjectbleeding timeen_US
dc.subjecthemorrhageen_US
dc.subjecthemostasisen_US
dc.subjectraten_US
dc.titleEffects of Algan Hemostatic Agent on bleeding time in a rat tail hemorrhage modelen_US
dc.typeArticle

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